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KMID : 0370220140580010001
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Yakhak Hoeji
2014 Volume.58 No. 1 p.1 ~ p.6
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Effects of Silibinin and Resveratrol on Degradation of IκB and Translocation of NF-κB p65 Induced by Tumor Necrosis Factor-α in Cultured Airway Epithelial Cells
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Park Soo-Hyun
Lee Hyun-Jae
Ryu Ji-Ho
Lee Su-Yel
Shin Hyun-Dae
Hong Jang-Hee
Seok Jeong-Ho
Lee Choong-Jae
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Abstract
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We examined whether silibinin and resveratrol affect airway mucin production, degradation of IκB and translocation of NF-κB p65 induced by TNF-α in NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with TNF-α for 24 h or the indicated periods. The two compounds suppressed TNF-α-induced airway mucin production, degradation of IκB and translocation of NF-κB p65. This result suggests that silibinin and resveratrol can regulate the production of mucin induced by TNF-α through the inactivation of NF-κB pathway in airway epithelial cells.
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KEYWORD
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airway mucin, MUC5AC, natural products
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FullTexts / Linksout information
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